Nerandomilast (Jascayd) is a new oral medication used to treat adults with idiopathic pulmonary fibrosis (IPF). The U.S. Food and Drug Administration (FDA) approved nerandomilast in 2025. It’s the first new treatment for IPF in more than a decade.e60dc2a1-f33c-4a05-9b50-8e3e8e597629c79ef89a-1b64-4133-ac43-e50564d91a01 IPF is an incurable condition that causes scarring of the lungs. The damage worsens over time and makes it hard to catch your breath. As IPF progresses, it becomes difficult to breathe, even at rest.e60dc2a1-f33c-4a05-9b50-8e3e8e597629067b5692-5e0d-45eb-b174-9af21579168c Nerandomilast is in a class of drugs called phosphodiesterase 4B (PDE4B) inhibitors. It helps slow the lung function decline in IPF. This can help people with IPF feel better for longer.e60dc2a1-f33c-4a05-9b50-8e3e8e597629c79ef89a-1b64-4133-ac43-e50564d91a01
How Does Nerandomilast Work? Function Nerandomilast works by blocking the enzyme PDE4B. When PDE4B is overactive, it can cause inflammation and tissue damage. Targeting the PDE4B enzyme helps slow lung scarring.e60dc2a1-f33c-4a05-9b50-8e3e8e5976296912363e-afd5-4627-aca8-e20adc23def4 In clinical trials, people who took nerandomilast experienced a slower decline in lung function than those who took a placebo pill. That means the medication kept their lungs working better over time. While it doesn’t cure IPF, nerandomilast can delay its progression.e60dc2a1-f33c-4a05-9b50-8e3e8e5976291e9d8cbd-47a6-42e9-bf4c-ed29548ef050
What Are the Possible Side Effects of Nerandomilast? Side Effects Like most medications, nerandomilast can cause side effects. The most common issues reported are:e60dc2a1-f33c-4a05-9b50-8e3e8e597629ffe6e5ee-97b1-40d6-93fb-538a5899d028 Diarrhea Weight loss Headache COVID-19 Poor appetite Vomiting Nausea Upper respiratory infection Back pain Fatigue Dizziness Depression
Are There Any Risks Related to Nerandomilast? Risks In clinical trials, nerandomilast was safe and well tolerated.e60dc2a1-f33c-4a05-9b50-8e3e8e597629154693c3-2a98-48e3-9293-3d69c5d8dac0 Before you take nerandomilast, tell your doctor about all the medical conditions you have, especially any kidney or liver issues. Also, let your healthcare provider know if you: Are pregnant Plan to become pregnant Are breastfeeding Plan to breastfeed It’s not known if nerandomilast can harm a fetus or pass into breast milk. Some data suggests the medication could cause a miscarriage. Nerandomilast is intended for adults. Doctors don’t know if it’s safe or effective in children. This medication may affect the way other drugs work. Tell your healthcare provider about all the prescription, nonprescription, recreational (including illegal), herbal, nutritional, or dietary drugs you’re taking while using nerandomilast. Your doctor may have to adjust your dosage if you also take medications called CYP3A inhibitors or CYP3A inducers. If you take too much nerandomilast, call your doctor or poison control at 800-222-1222, or go to the nearest emergency room right away.e60dc2a1-f33c-4a05-9b50-8e3e8e597629ae247b53-edf7-4df6-8856-808ae8dadcd7
How Do You Take Nerandomilast? How to Take Nerandomilast comes as a tablet to take by mouth. You can take this drug with or without food. If you can’t swallow the tablet, it can be mixed with water to drink. Follow the instructions on your package label carefully. The recommended dosage is 18 milligrams (mg) about every 12 hours. Your doctor can lower your dose if you experience side effects. If you miss a dose of nerandomilast, skip it and take your next dose at the scheduled time. Don’t double up on doses.e60dc2a1-f33c-4a05-9b50-8e3e8e5976294e14020c-58aa-47ad-b0bc-9c4e7058e3e0
The Takeaway Nerandomilast is the first new treatment approved for IPF in more than 10 years. The medication doesn’t cure IPF, but it can slow how fast it progresses. Generally, nerandomilast causes mild side effects, with diarrhea being the most common. Always discuss all the drugs you’re taking with your healthcare provider.
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