Is Rybelsus as Effective as Ozempic?
Rybelsus can also be an effective type 2 diabetes treatment, like Ozempic, but it’s important to note each are absorbed differently, and are therefore available different doses.
According to the FDA, the maximum 14 milligram (mg) daily dose of Rybelsus is equivalent to the 0.5 mg weekly dose of Ozempic; one can be switched for the other without the need for a dose adjustment. (Rybelsus uses higher amounts of semaglutide than Ozempic, because only a fraction of the semaglutide that enters the stomach is properly absorbed.)
A study of real-world data found oral semaglutide demonstrated “similar effectiveness” to injectable semaglutide for blood sugar control.
While these results suggest that Rybelsus and Ozempic could be similarly effective for people with type 2 diabetes, the two drugs are not equivalent, practically speaking, because Ozempic is available in more powerful dosages.
Ozempic is additionally available in 1 and 2 mg doses. The maximum dose, when tested in people with type 2 diabetes using metformin, led to an A1C drop of 2.2 percentage points, and weight loss of just over 15 pounds. Rybelsus can’t match these results — at least not at the approved doses. Wegovy is approved in even higher doses, a 2.4 mg per week injection and a 25 mg per day pill.
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