Some studies have found a possible small link between the flu shot and Guillain-Barré syndrome, a progressive nerve disorder that can cause profound weakness for weeks or longer. Overall, these studies estimated the risk after vaccination as fewer than 1 or 2 cases per one million people vaccinated.
As with any medicine, there is a very remote chance that a flu vaccine can cause a serious allergic reaction (anaphylaxis), other serious injury, or even death.
The CDC has announced a change that began in 2023–2024 related to recommendations for flu vaccines for people with egg allergies.
Although almost all flu vaccines today continue to be produced using an egg-based manufacturing process (and contain a small amount of egg proteins, such as ovalbumin), the current recommendation is that it’s safe for people with egg allergies to receive any flu vaccine — egg-based or non-egg-based — that is appropriate for their age and health status.
Additional safety measures used to be recommended, but that’s no longer the case.
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