Freezing in Advanced Parkinson’s: Causes, Triggers, and Treatments

Staff
By Staff
2 Min Read

To treat freezing episodes, your healthcare provider will want to know how often they happen and their timing related to your medication schedule. For example, they may ask, “How close to your next dose do you typically freeze?”

Once they have a clear picture of your FOG symptoms, they can recommend treatment options.

Medications and Dosing

“Medication adjustments are often the first step, since freezing can be linked to low dopamine levels or medications wearing off,” says Ejaz Shamim, MD, a neurologist at Kaiser Permanente in Maryland. Your provider may first suggest increasing your dosage of medications that boost dopamine production, like carbidopa-levodopa (Sinemet).

But sometimes, even when you get the right dose, freezing can continue. Beyond adjusting dopamine-stimulating medication, it’s worth trying other medications, like amantadine (Symmetrel), droxidopa (Northera), or stimulants like atomoxetine (Strattera), says Liao.

Apomorphine (Kynmobi), a fast-acting medication that helps your body use dopamine, can quickly relieve freezing and is available as a small injection or a dissolving film under the tongue, says Dr. Shamim. But it comes with side effects like mouth dryness and irritation, which may limit how much you can use it.

Deep Brain Stimulation

Researchers have studied using deep brain stimulation (DBS) for FOG with promising results, says Liao. An FDA-approved treatment for Parkinson’s, DBS manages electric brain messages through a device surgically placed in the brain.

Treatments Under Research

Ongoing studies are testing new ways of preventing freezing in Parkinson’s, like brain training and wearable technology. “Many of these techniques are still in the research phase but will roll out to the general Parkinson’s patient population soon,” says Liao.

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