If you’re bothered by GI side effects from metformin, take these steps to help resolve your issues and possibly prevent them from happening again. Talk to your doctor about tweaking or switching your medication, if you decide together that it may improve your symptoms.
Try a Slower-Release Formulation of Metformin
Extended-release and delayed-release metformin formulations are designed to enter your body at a slower rate and are less likely to cause side effects. Research found that those who took long-acting metformin were less likely to experience adverse gastrointestinal events and more likely to stay on the drug.
Ask About a Lower Dosage
Lee says higher doses of metformin may result in more bothersome side effects. The highest approved dose for metformin is 2,550 milligrams, but Lee says some patients can only tolerate 1,000 milligrams in two doses split daily.
Studies show that higher doses are more effective, but it may be possible to find a sweet spot where the metformin provides the blood sugar effect needed without causing bellyaches.
Stay Hydrated
If you have either issue, replace lost fluids by drinking plenty of water, and also consider beverages that can help replace electrolytes, like zero-sugar sports drinks or bone broth.
Taking metformin with a meal and glass of water may also reduce gastrointestinal distress, preventing diarrhea from occurring in the first place.
Over-the-Counter Medications
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