Managing Chorea in Huntington’s Disease: Symptoms and Treatments

Staff
By Staff
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Side effects and limitations are an important consideration for any medication, and this is especially true of chorea treatment. It can be a balancing act of reducing involuntary movements without creating new problems that feel just as disruptive.

VMAT2 inhibitors can cause sleepiness, nausea, restlessness, and stiffness or slowed movement. In some people, they can tip the balance too far in the other direction, leading to more rigidity or parkinsonism-like symptoms.
The medications can have mood side effects as well, though sometimes it’s difficult to separate those from symptoms caused by Huntington’s disease itself. Tetrabenazine is the drug most closely linked with depression and suicidal thoughts. An adverse event study also found reports of suicidal ideation and parkinsonism across the VMAT2 class, though it could not prove the drugs caused those problems.
Antipsychotics can also cause a range of side effects, including abnormal movements, sleepiness, stiffness, and restlessness. Older antipsychotics generally have more side effects than newer, atypical options.

Treatment also has limits over time. Anti-chorea therapy should be reevaluated regularly, because as Huntington’s progresses, the focus of care may shift.

“Typically, as symptoms progress, the thinking, memory, and behavior symptoms are the more disabling features,” says Hill.

Also, some medications that help with some symptoms may cause side effects that include worsening other symptoms. People with Huntington’s disease may also develop other movement problems like dystonia (abnormal muscle contractions) or even Parkinson-like symptoms, she says.

Chorea treatment is often a balancing act, and that’s why regular check-ins with a neurologist are so important: The best treatment or treatments early on may not still be the right ones later.

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