Subtle emotional shifts while on GLP-1 medications may not be cause for concern, but it’s worth paying attention to psychological changes that interfere with daily life.
“It really comes down to hobbies,” Nadolsky says. “Like when you stop wanting to participate in things you enjoyed before [going on GLP-1s].”
Other signs that Naidoo recommends watching for include:
- Persistent emotional flatness lasting more than two weeks
- Withdrawing from friends or routines
- Low motivation
- A sense that nothing feels rewarding
If healthy lifestyle factors like maintaining a structured exercise routine, eating a nutritious diet, getting enough sleep, and making time for social activities don’t seem to be effective for your emotional well-being while on a GLP-1 medication, it’s a good idea to check in with a clinician, Dr. Shah says. “If you feel that the severity of your emotional side effects is high and the duration has been persistent — immediately see your provider.”
A healthcare provider can help with weighing the benefits you’re getting from GLP-1 medications against any emotional side effects you may be experiencing — potentially adjusting dosage or medication type and recommending additional mental health support, if needed.
“Dialing in the correct dose is important, but also community with others going through the same journey,” says Nadolsky.
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